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PEER- REVIEWED PUBLICATIONS:

  • Johnson, B.A. and Frostig, R.D. Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture. Frontiers in Neuroanatomy 12:50. doi: 10.3389/fnana.2018.00050, 2018. Click for PDF.
  • Hancock, A.M. and Frostig, R.D. Testing the effects of sensory stimulation as a collateral-based therapeutic for ischemic stroke in C57BL/6J and CD1 mouse strains. PLoS ONE 12(9):e0183909. https://doi.org/10.1371/journal. pone.0183909. 2017. Click for PDF.
  • Frostig, R.D., Chen-Bee, C.H., Johnson, B.A. and Jacobs, N.S. Imaging Cajal’s neuronal avalanche: how wide-field imaging of the point-spread advanced the understanding of neocortical structure-function relationship. Neurophotonics, DOI: 10.1117/1.NPh.4.3.031217, 2017. Click for PDF.
  • Jacobs, N.S. and Frostig, R.D. Prominent lateral spread of imaged evoked activity beyond cortical columns in barrel cortex provides foundation for coding whisker identity. Neurophotonics, DOI: 10.1117/1.NPh.4.3.031218, 2017. Click for PDF.
  • Qi, L., Zhu, J., Hancock, A.M., Dai, C., Zhang, X, Frostig, R.D. and Chen, Z. Fully distributed blood flow velocity for middle cerebral arteries using Doppler optical coherence tomography. Biomedical Optics Express, DOI: 10.1364/BOE.7.000601, 2016. Click for PDF.
  • Konecky, S.D., Wilson, R.H., Hagen, N., Mazhar, A., Tkaczyk, T.S., Frostig, R.D. and Tromberg, B.J. Hyperspectral optical tomography of intrinsic signals in the rat cortex. Neurophotonics, DOI: 10.1117/1.NPh.2.4.045003, 2015. Click for PDF.
  • Johnson, B.A.  and Frostig, R.D. Long, intrinsic horizontal axons radiating through and beyond rat barrel cortex have spatial distributions similar to horizontal spreads of activity evoked by whisker stimulation, Brain Structure Function DOI 10.1007/s00429-015-1123-7, 2015. Click for PDF
  • Johnson, B.A. and Frostig R.D. Photonics meets connectomics: case of diffuse, long horizontal projections in rat cortex. Neurophotonics, doi:10.3389/fncir.2015.00034. eCollection 2015. Click for PDF
  • Jacobs, N.S., Chen-Bee, C.H. and Frostig R.D. Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Frontiers in Neural Circuits, 9:34. doi: 10.3389/fncir.2015.00034. eCollection 2015. Click for PDF
  • Lay, C. C. and Frostig, R.D. Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats. European Journal of Neuroscience, doi:10.1111/ejn.12723, 2014. Click for PDF
  • Stehberg, J. Dang, P.T. and Frostig, R.D.Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex. Frontiers in Neuroantomy, doi:10.3389/fnana, 2014. Click for PDF
  • Hancock, A.M., Lay, C.C., Davis, M.F. and Frostig, R.D. Sensory stimulation-based complete protection from ischemic stroke remains stable at 4 months post-occlusion of MCA. Journal of Neurological Disorders, 1: 135. doi:10.4172/2329-6895.1000135, 2013. Click for PDF
  • Lay, C.C., Jacobs, N., Hancock, A.M., Zhou, Y. and Frostig, R.D. Complete sensory-induced protection from ischemic stroke under isoflurane anesthesia. doi: 10.1111/ejn.12217. European Journal of Neuroscience, 2013. Click for PDF.
  • Chen-Bee, C.H., Zhou, Y, Jacobs, N., Lim, B. and Frostig, R.D. Whisker array functional representation in the rat barrel cortex: transcendence of one-to-one topography and its underlying mechanism. Frontiers in Neural Circuits, doi: 10.3389/fncir, 2012. Click for PDF
  • Davis, M.F., Lay, C., and Frostig, R.D. Permanent Cerebral Vessel Occlusion Via Double Ligature and Transection. Journal of Visualized Experiments, e50418, doi:10.3791/50418, 2013. Click for PDF
  • Frostig, R.D. Lay, C., and Davis, M.F. A rat’s whiskers point the way towards a novel stimulus-dependent, protective stroke therapy. The Neuroscientist, DOI: 10.1177/1073858412462607, 2012. Click for PDF
  • Frostig, R.D. and Chen-Bee, C.H. The use of intrinsic signal optical imaging for mapping cortical function. In: Romain Brette, Alain Destexhe (Eds.) Handbook of Neuronal Activity Measurements. Cambridge University Press, 2012. Click for PDF
  • Christopher C. Lay, Melissa F. Davis, Cynthia H. Chen-Bee and Ron D. Frostig. Mild sensory stimulation protects the aged rodent from cortical ischemic stroke after permanent middle cerebral artery occlusion. Journal of the American Heart Association (JAHA), doi: 10.1161/JAHA.112.001255; 2012. Click for PDF
  • Christopher C. Lay, Melissa F. Davis, Cynthia H. Chen-Bee and Ron D. Frostig. Mild sensory stimulation reestablishes cortical function during the acute phase of ischemia. Journal of Neuroscience, 31(32):11495–11504; 2011. Click for PDF
  • Gomez-Pinilla Fernando, Ying Zhe. Agoncilloa Teodora and Ron D Frostig. The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: Effects of whisker use. Brain Research, 1388 39-47; 2011. Click for PDF
  • Melissa F. Davis, Christopher C. Lay, Cynthia H. Chen-Bee and Ron D. Frostig. Amount but not pattern of protective sensory atimulation alters recovery after permanent middle cerebral artery occlusion. Stroke. 42;792-798; 2011. Click for PDF
  • Lay CC,  Davis MF,  Chen-Bee CH,  Frostig RD. Mild sensory stimulation completely protects the adult rodent cortex from ischemic stroke. PLoS ONE 5(6): e11270.doi:10.1371/journal.pone.0011270, 2010. Click for PDF

  • Chen-Bee, C.H., Agoncillo, T., Layc C.C., Frostig, R.D. Intrinsic signal optical imaging of brain function using short stimulus delivery intervals. Journal of Neuroscience Methods, 01(009), 2010. Click for PDF
  • Abookasis D, Lay CC, Mathews MS, Linskey ME, Frostig RD, Tromberg BJ. Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. Journal of Biomedical Optics, 14 (2): 024033, 2009. Click for PDF

  • Frostig RD, Xiong Y, Chen-Bee CH, Kvasnák E, Stehberg J. Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads. Journal of Neuroscience, 28 (49): 13274-84, 2008. Click for PDF

  • Chen-Bee, C.H., Agoncillo, T., Xiong, Y., Frostig, R.D. The tri-phasic intrinsic signal: implications for functional imaging. Journal of Neuroscience, 27 (17): 4572 - 4586, 2007. Click for PDF

  • Frostig, R.D., Functional organization and plasticity in the adult rat barrel cortex: moving out-of-the-box. Current Opinion in Neurobiology, 16:1-6, 2006. Click for PDF

  • Polley, D.B., Rickert, J., and Frostig, R.D. Whisker-based discrimination of object orientation determined with a rapid training paradigm. Neurobiology of Learning and Memory, 83, 134-142, 2005. Click for PDF

  • Prakash, N. and Frostig, R.D. What has intrinsic signal optical imaging taught us about NGF-induced rapid plasticity in adult cortex and its relationship to the cholinergic system? Molecular Imaging and Biology, 7, 14-21, 2005 (Epub 12-30, 2004). Click for PDF

  • Polley, D. B., Kvasnak, E. and Frostig, R.D.   Naturalisitic experience transforms sensory maps in the adult cortex of caged animals. Nature, 429, 67-71, 2004. Click for PDF

  • Prakash, N., Cohen-Cory, S., Penschuck, S. and Frostig, R.D. The basal forebrain cholinergic system is involved in rapid nerve growth factor (NGF)-induced plasticity in the barrel cortex of adult rats. Journal of  Neurophysiology, 91, 424-437, 2004. (Epub 09-24, 2003). Click for PDF

  • Penschuck, S., Chen-Bee, C., Prakash, N., and Frostig, R.D. In vivo modulation of a cortical functional sensory representation shortly after topical cholinergic agent application. Journal of Comparative Neurology , 452, 38-50, 2002. Click for PDF

  • Brett-Green, B., Chen-Bee, C.H., and Frostig, R.D. Comparing the functional representations of central and border whiskers in the rat primary somatosensory cortex. Journal of Neuroscience, 15: 9944-9954, 2001. Click for PDF

  • Prakash, N., Vanderhaeghen, P., Cohen-Cory, S., Frisén., J., Flanagan, J.G., and Frostig, R.D. Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knockout mice revealed by in vivo functional imaging. Journal of Neuroscience, 20:5841-5847, 2000.
    Click for PDF

  • Vanderhaeghen, P., Lu, Q., Prakash, N., Frisen, J., Walsh , C.A. , Frostig, R.D., and Flanagan, J.G. A mapping label required for normal scale of body representation in the cortex. Nature Neuroscience, 3:358-365, 2000. Click for PDF

  • Chen-Bee, C., Polley, D.B., Brett-Green, B., Prakash, N., Kwon, M.C. and Frostig, R.D. Visualizing and quantifying evoked cortical activity assessed with intrinsic signal imaging. Journal of Neuroscience Methods, 97:157-173, 2000. Click for PDF

  • Polley, D.B., Chen-Bee, C., and Frostig, R.D. Two directions of plasticity in the sensory-deprived adult cortex.Neuron, 24:623-637, 1999. (Cover story, subject to preview). Click for PDF

  • Chen, Z., Zhao, Y., Srinivas, S., Nelson, J.S., Prakash, N., and Frostig, R.D. Optical Doppler Tomography. IEEE Journal of Selected Topics in Quantum Electronics, 1134-1142, 1999. Click for PDF

  • Polley, D.B., Chen-Bee, C. and Frostig, R.D. Varying the degree of single whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex. Journal of Neurophysiology, 81:692-701,1999. Click for PDF

  • Prakash, N., Cohen-Cory, S. and Frostig, R.D. Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo. Nature, 381: 702-706, 1996. 
    Click for PDF

  • Chen-Bee, C.H. and Frostig, R.D. Variability and interhemispheric asymmetry of the single-whisker functional representations in rat barrel cortex. Journal of Neurophysiology, 76:884-894, 1996. Click for PDF

  • Chen-Bee, C.H., Kwon, M., Masino , S.A. and Frostig, R.D. Areal extent quantification of functional representations using intrinsic signal optical imaging. Journal of Neuroscience Methods, 68:27-37, 1996. Click for PDF

  • Masino , S.A. and Frostig, R.D. Quantitative long-term imaging of the functional representation of a whisker in rat barrel cortex. Proceedings of the National Academy of Science USA , 93, 4942-4947, 1996. Click for PDF

  • Bakin, J.S., Kwon, M.C., Masino , S.A. , Weinberger , N.M. and Frostig, R.D. Suprathreshold auditory cortex activation visualized by intrinsic signal optical imaging. Cerebral Cortex, 6:120-130, 1996. Click for PDF

  • Carmona, R.A., Hwang, W, L. and Frostig R.D. Wavelet analysis for brain function imaging. IEEE Transactions on Medical Imaging, 14:556-564, 1995. Click for PDF

  • Grinvald, A., Lieke, E.E., Frostig, R.D., Hildesheim, R. Cortical point-spread function and long-range lateral interactions revealed by real-time optical imaging of macaque monkey primary visual cortex. Journal of Neuroscience, 14, 2545- 2568, 1994. Click for PDF

  • Masino, S., Kwon, M.C., Dory, Y. and Frostig, R.D. Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull. Proceedings of the National Academy of Science USA , 90, 9998-10002,1993. Click for PDF

  • Grinvald, A., Frostig, R.D., Siegel, R.M. and Bartfeld, E. High resolution optical imaging of functional brain architecture in the awake monkey. Proceedings of the National Academy of Science USA , 88, 11559-11563, 1991. Click for PDF

  • Frostig, R.D., Lieke, E.E., Ts'o, D.Y. and Grinvald, A. Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high resolution optical imaging of intrinsic signals. Proceedings of the National Academy of Science USA , 87, 6082-6086, 1990. Click for PDF

  • Ts'o, D.Y., Frostig, R.D., Lieke, E.E. and Grinvald, A. Functional organization of the primate visual cortex revealed by high-resolution optical imaging of intrinsic signals. Science, 249, 417-420, 1990.
    Click for PDF

  • Frostig, R.D. Codes embedded in neuronal activity. Notes on Theoretical Biology, 1: 57-74, 1990.

  • Frostig, R.D., Frostig, Z. and Harper, R.M. Recurring discharge patterns in multiple spike trains. I.   Detection. Biological Cybernetics, 62:487-493, 1990.

  • Frostig, R.D., Frysinger, R.C. and Harper, R.M. Recurring discharge patterns in multiple spike trains.    II. Application in forebrain areas related to cardiac and respiratory control during different sleep waking states. Biological Cybernetics, 62:495-502, 1990.

  • Frostig, Z, Frostig, R.D.   Analysis of frequency components in time series data. Journal of Neuroscience Methods, 22:79-87, 1987

  • Grinvald, A., Lieke, E., Frostig, R.D., Gilbert, C.D. and Wiesel, T.N. Functional architecture of the cortex revealed by optical imaging of intrinsic signals. Nature, 324:361-364, 1986 Click for PDF

  • Frostig, R.D., Frostig, Z. and Harper, R.M. Information Trains. The technique and its uses in spike train and network analysis, with examples taken from the nucleus parabrachialis medialis during sleep-waking states. Brain Research, 322:67-74 , 1984

  • Frostig, R.D., Gottlieb, Y., Vaadia, E. and Abeles, M. The effect of stimuli on the activity and functional connectivity of local neuronal groups in the cat auditory cortex. Brain Research, 272:211-221, 1983

  • Devor, M., Carmon, A. and Frostig, R.D. Primary afferents and spinal sensory neurons that respond to brief pulses of intense infrared laser radiation: a preliminary survey in rats. Experimental Neurology, 76:483-494, 1982

  • Carmon, A. and Frostig, R.D. Noxious stimulation of animals by brief intense laser induced heat: advantage to pharmacological testing of analgetics. Life Science, 29:11-16, 1981